Houston, Texas (August 17, 2010) – Donald W.
(Will) Parsons, M.D., a physician at Texas Children's Cancer Center and Baylor College of Medicine, has been honored with a 2010 Doris Duke Clinical Scientist Development
Award. Dr. Parsons, who works in collaboration with Dr. Richard Gibbs at Baylor
College of Medicine's Human Genome Sequencing Center, specializes in the genomic
analysis of brain tumors. With this award, Parsons will focus on advancing his research
in the development of large-scale (genomic) methods to identify and evaluate cancer-causing
mutations in gliomas, one of the most deadly types of brain tumors. His goal is
to rapidly identify genetic alterations that may serve as targets for new diagnostic
tests and treatments. To learn more about research going on in the Texas Children's
Cancer Center, see: http://texaschildrens.org/cancer.
Parsons is one of 12 physician-scientists nationally to receive this prestigious
award, and will receive $486,000 over three years from The Doris Duke Charitable
Foundation's Medical Research Program, to support his research studying pediatric
brain tumors.
"It is truly an honor to receive this award," says Parsons. "The sponsored research
will provide urgently-needed information about the biology of pediatric gliomas,
which we hope to translate into improved care for our patients. The award will also
provide valuable support for the development of my research career as an independent
physician-scientist scientist at Texas Children's Cancer Center."
Dr. Parsons' work has resulted in the identification of numerous mutated genes and
genetic pathways that contribute to tumor initiation and progression, providing
a novel view of the genetic landscape of human cancers. For example, his analysis
of glioblastoma multiforme (GBM), the most lethal brain tumor of both adults and
children, for the first time identified mutation of the isocitrate dehydrogenase
genes (IDH1 and IDH2) as a common and critical event in the development of gliomas.
This discovery has opened a new and potentially clinically-useful area of brain
tumor research. Further work evaluating the functional relation of these mutations
to glioma development and the applicability of this finding for diagnostic and therapeutic
purposes is ongoing.
"It's wonderful that the research Dr. Parsons is conducting has been recognized
and supported by this most prestigious and distinguished award," says Dr. David
Poplack, Director of Texas Children's Cancer Center. "His work is essential in our
long-term goal to finding a cure for brain tumors and we are thrilled that he has
been honored with this award."
Since 1998, the Doris Duke Medical Research Program has committed approximately
$360 million to strengthen and support clinical research, which advances the translation
of basic biomedical discoveries into new treatments, preventions and cures for human
diseases. To learn more about the program or to receive competition announcements,
visit www.ddcf.org/mrp.
Dr. Parsons' pediatric brain tumor research is also funded by the Alex's Lemonade
Stand Foundation, the Gillson-Longenbaugh Foundation, Golfers Against Cancer, the
Hoglund Foundation, and the Ready-or-Not Foundation.
About Texas Children's Cancer Center
As an international leader in pediatric cancer research and treatment, Texas Children's
Cancer Center is dedicated to providing novel therapies and family-centered care
to children from infancy through young adulthood with cancer and blood disorders
– from the most common to rare. Ranked 5th in the nation by U.S. News & World Report,
making the Center #1 outside the northeast United States as well as #1 in Texas,
Texas Children's Cancer Center treats more childhood cancer patients than any other
program in the U.S., with patients coming from 35 states and 26 countries around
the world. Learn more at www.txccc.org.
About Texas Children's Hospital
Texas Children's Hospital is committed to a community of healthy children by providing
the finest pediatric patient care, education and research. Renowned worldwide for
its expertise and breakthrough developments in clinical care and research, Texas
Children's is nationally ranked in all ten subspecialties in U.S.News & World Report's
list of America's Best Children's Hospitals. Texas Children's also operates the
nation's largest primary pediatric care network, with more than 40 offices throughout
the greater Houston community. Texas Children's has embarked on a $1.5 billion expansion,
Vision 2010, which includes the Jan and Dan Duncan Neurological Research Institute™,
a comprehensive obstetrics facility focusing on high-risk births and a community
hospital in suburban West Houston. For more information on Texas Children's Hospital,
go to www.texaschildrens.org. Get the
latest news from Texas Children's Hospital by visiting the online newsroom
http://www.texaschildrens.org/allabout/news/default.aspx and on Twitter
at twitter.com/texaschildrens.
