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The Center for Vaccine Awareness and Research

Vaccines by disease: Learning more about the
inactivated influenza vaccine

This vaccine is important because it protects against the influenza virus. Each year, approximately 220,000 people in the United States are hospitalized because of influenza (“the flu”), and 36,000 die. Nearly 100 of these deaths are in children. There are two kinds of influenza vaccines: the inactivated (killed) influenza vaccine and the live attenuated (weakened) influenza vaccine. Anyone 6 months of age or older can receive the inactivated vaccine but the live attenuated vaccine is recommended only for healthy, non-pregnant people without asthma between the ages of 2 and 49 years.

Influenza can cause high fevers, pneumonia and seizures in children. Prevention is the key to not contracting the flu, and the most effective preventive method is receiving an annual influenza vaccination.


Who should receive the inactivated influenza vaccine? 
Everyone 6 months of age or older should receive the inactivated influenza vaccine annually.

Who should not be given Inactivated Influenza?

  • People who have a severe allergy
  • People with severe allergies to any vaccine component
  • People who are moderately or severely ill. They should wait until they have recovered to get this vaccine.

How long after receiving the flu vaccine does it take to become protected?
It can take up to two weeks for inactivated influenza vaccine to become fully effective. The best time to get this vaccine is as soon as it is available in September or October. Even a late vaccination in January (or later) can be beneficial. Flu season may start as early as October usually peaks in February and can extend through late May.
 

When did the inactivated influenza vaccine become available?
Since 1945, influenza vaccines have been available in the United States. The vaccine is modified each year with three virus strains that are predicted to be in the United States during the upcoming winter. The inactivated (killed) vaccine (TIV), commonly referred to as the flu shot, is given by injection. A second flu vaccine, the live attenuated influenza vaccine (LAIV) is given via nasal spray (a separate description of this vaccine is available for review).

How does someone become infected with influenza?
Influenza is most commonly spread from person to person. It also may be spread when a healthy person touches something with the flu virus on it (e.g., hands of an infected person, discarded tissue, etc) and then touches the nose or mouth.

How effective is the inactivated influenza vaccine?
When the virus strains in the vaccine match those viruses circulating in the U.S., the inactivated influenza vaccine can protect between 45 percent and 90 percent of vaccinated people. Inactivated influenza vaccine also decreases middle ear infections in young children by approximately 30 percent.

The inactivated influenza vaccine may prevent up to 90 percent of influenza cases in vaccinated healthy adults under the age of 65.

Are there any serious side effects of the inactivated influenza vaccine?
Serious side effects from the inactivated influenza vaccine are quite rare. Mild side effects may include injection site soreness and fever.

Can the vaccine give you the flu?
It is a myth that inactivated influenza vaccine causes influenza. The inactivated vaccine contains killed viruses and cannot give you the flu.

How do I learn more about this vaccine?
The best person to ask about this or any vaccine is your child’s pediatrician or your primary health care provider. Your provider can answer your questions and give you more information on the inactivated influenza vaccine.

Immunization is the best thing you can do for your child and yourself to protect against influenza.